Fig. 4: GSEA on sex interaction estimates of cortical thickness in iRBD.
a Violin plots showing the percentage of variance in sex interaction estimates explained by gene expression; the dot represents the empirical variance, and the asterisk indicates the components that were significant against spatial null models. b Scatterplot of the association between the sex interaction estimates and the regional weights of the first and third c latent variables. Pearson’s correlation coefficient (r) and corresponding P-value are reported. The red line shows the linear regression fit, and the shaded error band represents the 95% confidence interval (CI) of the fit. d Brain maps of the sex interaction coefficients and their regional weights for the first and third (f) latent variables. e, g The top ten molecular function terms from the Gene Ontology knowledge base that are enriched in the positively and negatively weighted gene sets associated with sex effect on cortical thickness in iRBD. Terms are ranked based on the normalized enrichment score; darker colored bars present significantly enriched terms after FDR correction. Brain maps were generated with SurfIce77. FDR = false discovery rate; GSEA = gene set enrichment analysis; iRBD = isolated REM sleep behavior disorder; LV = latent variable; PLS = partial least square.
