Table 3 Molecular functions enriched in regions with sex interaction for LV1

From: Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder

GO identifier

GO term

Gene set size

Number of leading edge IDs

Enrichment score

Normalized enrichment score

FDR P-value

Positively weighted genes with sex interaction (females > males)

GO:0003707

nuclear steroid receptor activity

20

8

0.65

1.95

0.027

GO:0004984

olfactory receptor activity

48

38

0.45

1.69

0.13

GO:0004386

helicase activity

138

46

0.36

1.62

0.17

GO:0140993

histone modifying activity

187

61

0.33

1.61

0.16

GO:0003727

single-stranded RNA binding

72

36

0.38

1.55

0.22

Negatively weighted genes with sex interaction (females < males)

GO:0140104

molecular carrier activity

83

35

−0.41

−1.65

0.11

GO:0016645

oxidoreductase activity, acting on the CH-NH group of donors

25

12

−0.56

−1.73

0.07

GO:0043177

organic acid binding

145

54

−0.41

−1.75

0.07

GO:0001664

G protein-coupled receptor binding

193

57

−0.39

−1.77

0.08

GO:0005507

copper ion binding

45

18

−0.51

−1.78

0.10

  1. Bold values represent significantly enriched gene terms. Only the top 10 gene terms are shown (redundancy reduction weight set cover applied).
  2. FDR = false discovery rate; GO = gene ontology; LV = latent variable.
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