Fig. 4: Interaction and co-regulation of adjacent D modifications in human ct-tRNA.
From: Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution
a An integrated overview of the cis-regulation of D20 by D20a, indicating that D20a modification is installed prior to D20. b Comparison of D modification levels at D20 sites in HepG2 tRNAs categorized into two groups: “grouped” (tRNAs containing both D20 and D20a sites, n = 10) and “others” (n = 18), following DUS2L and DUS4L depletion. c Comparison of D modification levels at D20a sites in HepG2 tRNAs categorized into two groups: ‘grouped’ (tRNAs containing both D20 and D20a sites, n = 10) and “others” (n = 6), following DUS2L and DUS4L depletion. Each point was calculated as the average of at least two biological replicates.
