Fig. 4: Schematics and characterizations of the multiplexed biosensor. | Nature Communications

Fig. 4: Schematics and characterizations of the multiplexed biosensor.

From: Soft bioelectronics embedded with self-confined tetrahedral DNA circuit for high-fidelity chronic wound monitoring

Fig. 4

a Illustration of wound-associated proteins released from the wound and the biochemical sensing mechanism. Created in BioRender. Xiao, X. (2025) https://BioRender.com/alwdc8p. b Digital photograph of a multiplexed sensing electrode. Scale bar, 1 cm. c A three-electrode nanofiber-based flexible sensor for the detection of protein biomarkers using SWV in AWF. CE, counter electrode; WE, working electrode; RE, reference electrode. SWV and calibration curves of TNF-α (d), IL-6 (e), TGF-β1 (f), and VEGF (g) in artificial wound fluid (n = 3 independent experiments). Data are presented as mean ± SD. h Schematic diagram illustrating the mechanism of the ELISA kit for detecting TNF-α. Created in BioRender. Xiao, X. (2025) https://BioRender.com/pqrm4ok. i Validation of the TDNA-based sensor towards TNF-α detection in AWF with ELISA. Calibration curve of the pH sensor (j) and temperature sensor (k) versus pH values and temperature values, respectively (n = 5 independent experiments). Data are presented as mean ± SD. Source data from (d–g, i–k) are provided as a Source Data file.

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