Fig. 7: Characterizing shared and distinct spatial transcriptome profiles associated with GZMK+ and GZMB+ in CD8+ T cells in salivary glands. | Nature Communications

Fig. 7: Characterizing shared and distinct spatial transcriptome profiles associated with GZMK+ and GZMB+ in CD8+ T cells in salivary glands.

From: Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation

Fig. 7

a Expression of GZMK and GZMB in spatial regions containing CD8+ T cells. b The top 10 and bottom 10 genes correlating with GZMK and GZMB expression in spatial regions containing CD8+ T cells, along with their correlation coefficients by Spearman’s correlation test. c Venn diagram displaying the up-regulated pathways along with expression of GZMK and GZMB, respectively. d Gene Set Enrichment Analysis (GSEA) comparing GZMK and GZMB correlated genes. Only selected pathways with significance (false discovery rate (FDR) < 0.05) are shown. The size of the dots represents the set size of genes involved, and the color intensity indicates the normalized enrichment score (NES).

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