Fig. 5: Pt(IV) prodrugs as photocrosslinkers for hydrogelation and protein labeling. | Nature Communications

Fig. 5: Pt(IV) prodrugs as photocrosslinkers for hydrogelation and protein labeling.

From: Harnessing platinum(IV) prodrugs as versatile photoinitiators and photocrosslinkers for multifunctional hydrogels and protein labeling

Fig. 5: Pt(IV) prodrugs as photocrosslinkers for hydrogelation and protein labeling.The alternative text for this image may have been generated using AI.

a Schematic illustration of the hydrogelation of gelatin. b Photographs of Pt(IV)-gelatin hydrogels at a gelatin concentration of 5% with or without irradiation (365 nm, 9.8 mW/cm2, 10 min). Pt(II) as controls were carried out simultaneously. c Rheology measurements of Pt-gelatin hydrogel and gelatin. d TGA curves of gelatin and Pt-gelatin hydrogel with different concentrations of cisPt(IV)−1. e Raman spectra of Pt-gelatin hydrogel and gelatin. The additional signal of Pt-gelatin is highlighted in blue. f Design of the Pt(IV)-based photocrosslinker. g Photolabeling of BSA by the Pt(IV)-based photocrosslinker (365 nm, 9.8 mW/cm2, 5 min). The labeled BSA was analyzed by gel fluorescence and Coomassie blue. h Quantification of the gel fluorescence intensity. Data are presented as mean ± SD from two independent experiments (n = 2). i Time-resolved BSA labeling by switching off the photostimuli. Source data are provided as a Source Data file.

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