Fig. 3: Structure of the UQ1 bound in S. cerevisiae SDH. | Nature Communications

Fig. 3: Structure of the UQ1 bound in S. cerevisiae SDH.

From: Cryo-EM structure of the yeast Saccharomyces cerevisiae SDH provides a template for eco-friendly fungicide discovery

Fig. 3

a Determination of heme in SDH by absorbance spectrometry. Reduced heme has a characteristic absorption peak at 560 nm. The presence of heme can be detected in the reduced SsSDH, while it cannot be detected in the reduced ScSDH. b The electron transfer pathway of ScSDH. Prosthetic groups in the path of electron transfer are labeled with edge-to-edge distances. Four prosthetic groups, FAD, [2Fe-2S], [4Fe-4S], and [3Fe-4S] are required for electron transfer flow from succinate to ubiquinone. c The interaction of UQ1 with ScSDH. The UQ1 is surrounded with B_190Pro, B_194Trp, B_239Ile, C_94Ser, C_97Arg and D_120Tyr.

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