Fig. 2: Illustrated overview of SmartLid technology.

a SmartLid is composed of two main components, a disposable clear plastic lid, designed to press-fit into most 2 mL flip-cap or screw-cap tubes, and a removable magnetic key, housing a 5 mm × 5 mm N42 neodymium magnet. b Magnetic beads are collected onto SmartLid when the magnetic key is inserted, and the tube is inverted. A fluid wicking spike on the underside of the lid reduces buffer carry-over from tube to tube. c The entire magnetic beads collection, transfer, and resuspension process is illustrated, which occurs multiple times throughout the SmartLid extraction process. Created in BioRender. Cavuto, M. (2025) https://BioRender.com/rwbh4tn.