Table 1 Predicted AT2 cell receptor activation from up-stream regulator analysis

From: mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

Upstream Regulator

Molecule Type

Activation (z-score)

Target Molecules in Dataset

ESR2 Oestrogen receptor β

ligand-dependent nuclear receptor

2.209

CCND1, CDKN1A, CXCL8, FOS, GADD45B, H2AX

TLR7 Toll-like receptor 7

transmembrane receptor

2.178

CCND1, CCND3, CDKN1A, CEBPB, CXCL8, SOD2

TNFRSF1A TNF receptor superfamily member 1A

transmembrane receptor

1.994

CDKN1A, CEBPB, CXCL8, JUN, SOD2

IL6R Interleukin 6 receptor

transmembrane receptor

1.982

CDKN1A, CXCL8, NAMPT, STAT3

CAV1 Caveolin 1

transmembrane receptor

1.911

CCND1, CDKN1A, FOS, ID1

IGF1R Insulin dependent growth factor receptor 1

transmembrane receptor

1.698

CCND1, CDKN1A, CEBPB, FOS, ID2, STAT3

GPER1 G Protein-Coupled Oestrogen Receptor

G-protein coupled receptor

1.679

CCND1, CDKN1A, FOS, JUN, RASD1

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