Fig. 3: NBS1 interactions with the MR complex mediated by the C helix. | Nature Communications

Fig. 3: NBS1 interactions with the MR complex mediated by the C helix.

From: Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2

Fig. 3: NBS1 interactions with the MR complex mediated by the C helix.

A Overview of the MRN-DNA complex structure in ribbon model. B NBS1 sequence alignment (Hs: Homo sapiens, Mm: Mus musculus, Gg: Gallus gallus, Dr: Danio rerio, Xt: Xenopus tropicalis, Rn: Rattus norvegicus, Ss: Sus scrofa, Lc: Latimeria chalumnae) highlighting the conservation of F744 (numbered according to HsNBS1). C, D Close-up views of the interactions formed between NBS1 C helix and MRE11 or RAD50, respectively. Only interacting residues were displayed as sticks here for simplicity, and the black dashed lines represent electrostatic interactions or hydrogen bonds. E Associations of NBS1 C helix with ATM (PDB: 7SID) illustrated in a similar view to D for the purpose of side-by-side comparison.

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