Table 2 Examples of clinical workup in patients with early-stage cancer and rapid diagnosis following a positive MCED test result

From: Real-world data and clinical experience from over 100,000 multi-cancer early detection tests

Patient

Age Range (years)/sex

CSO Prediction

Days to Diagnosisa

Diagnostic Evaluation

Final Diagnosis

Test

Result

1

65–69/male

Pancreas/Gallbladder

34

CA19-9

Elevated

Stage I Pancreatic adenocarcinoma

MRCP

1.3 × 1.2 cm pancreatic lesion

Endoscopic ultrasound-guided biopsy

Cyst fluid negative; histology showed adenocarcinoma

2

60–64/male

Stomach/Esophagus

20

CT chest/abdomen/pelvis

Small esophageal mucosal mass

Stage I Esophageal adenocarcinoma

Upper endoscopy and biopsy

Adenocarcinoma

3

60–64/female

Liver/Bile Duct

26

CT chest/abdomen/pelvis

Multiple liver lesions

Stage II Hepatocellular carcinoma

CT-guided biopsy

Hepatocellular carcinoma

4

60–64/male

Liver/Bile Duct

32

CT abdomen

1.5 cm liver lesion

Stage I Hepatocellular carcinoma

CT-guided biopsy

Hepatocellular carcinoma

  1. CA 19-19 carbohydrate antigen 19-19, CT computed tomography, MRCP Magnetic Resonance Cholangiopancreatography.
  2. aTime from return of a positive MCED test result report to clinical diagnosis.
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