Fig. 5: Organismal benefits of homeostasis of glucose and lipid metabolism. | Nature Communications

Fig. 5: Organismal benefits of homeostasis of glucose and lipid metabolism.

From: Homeostasis of glucose and lipid metabolism during physiological responses to a simulated hypoxic high altitude environment

Fig. 5: Organismal benefits of homeostasis of glucose and lipid metabolism.The alternative text for this image may have been generated using AI.

a Body weight changes in EPAS1V162T/V162T and EPAS1+/+ mouse individuals under normoxia (n = 13 vs 11) and hypoxia (n = 10 for each group). The bars show mean ± SD. Two-way repeated measures ANOVA with corrections was applied. b Differential expression levels of genes playing a role in reactive oxygen species (ROS) metabolism in falconized mice compared to wildtype mice. Up- and down-regulated genes are in pink and blue, respectively. GSH: Glutathione, GSSG: oxidized Glutathione, γ-Glu-Cys: γ-Glutamyl-Cysteine, γ-Glu-amino acid: γ-Glutamyl-amino acid, Cys: Cysteine, Cys-Gly: Cysteinyl-Glycine, R-S-Cys-Gly: R-S-Cysteinyl-Glycine, R-S-Cys: R-S-Cysteine. Cx: Complex, OMM: Outer membrane, IMM: Inner membrane. c Comparison of survival rates between EPAS1V162T/V162T (n = 30) and EPAS1+/+ (n = 30) mouse individuals under acute hypoxia (4% O2) based on the Kaplan-Meier survival analysis. Source data are provided as a Source Data file.

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