Fig. 2: Exploration of the conformational landscape of phosphorylated structures.
From: Global comparative structural analysis of responses to protein phosphorylation
a Diagram depicting the procedure used to obtain low-dimensional representations of domain-specific structural spaces. b Stacked bar chart summarizing the proportion of phosphorylated structures, per domain, that are within a cluster containing at least one non-phosphorylated structure. Non-clustered proteins (gray) refers to structures labeled as not belonging to a specific cluster by HDBSCAN. c Scatterplots illustrating the clustering of phosphorylated and non-phosphorylated structures in six different low-dimensional, domain-specific representations. Blue dots represent non-phosphorylated structures, while other colors indicate specific phosphorylation states. Phosphosite indexes in the legend are assigned based on sequence alignments of the analyzed structures. d Examples of representatives structures from each cluster obtained for the eukaryotic aspartyl protease domain (PF00026). Source data are provided as a Source Data file.
