Fig. 3: miR-190a-5p expression predicts kidney disease progression in patients with low to moderate proteinuria and is reduced in kidney tissue in patients with declining kidney function.

A Kaplan-Meier survival curve for progression of kidney disease. Patients within the seNSOR cohort were segregated into groups by severity of albuminuria and whether serum miR-190a-5p levels were above (dashed line) or below (solid line) the median value. ACR: urinary albumin:creatinine ratio. The Log-rank test was used to compare curves. B Schemata of human CKD biopsy tissue being processed for quantification of miR-190a-5p expression, fibrosis, tubular mass by CD10/PanCK staining, and linked to clinical data. Created in BioRender. Denby, L. (2025) https://BioRender.com/ee0461g (C–F) miR-190a-5p in renal biopsy tissue from patients within the seNSOR cohort correlates with (C). miR-190a-5p transcript abundance in the circulation (n = 14 paired samples). For the determination of linear correlation between variables, correlation coefficients (r) were generated using Pearson’s test. Circulating miR-190a-5p expression was log-transformed before entering the model due to non-normal distribution (D). kidney function as determined by eGFR (n = 26 biopsy samples). Analysed by Pearson’s correlation (E), negatively with percentage fibrosis (n = 25 biopsy samples). Analysed by Pearson’s correlation (F), tubular mass as measured by CD10:PanCK staining of biopsy core (n = 24 biopsy samples).