Fig. 4: CSF treatment perturbed the spatial distribution of Pma1 within Candida glabrata plasma membranes.
From: Molecular landscape of the fungal plasma membrane and implications for antifungal action
Slice views of tomograms of untreated (a) and CSF-treated wild type cell membranes (b). c Zoomed-in view of dispersed Pma1 hexamers boxed in (b). Slice views of tomograms of untreated (d) and CSF-treated KH238 cell membranes (e). f Zoomed-in view of a small, tightly packed Pma1 cluster boxed in (e). g Intra-cluster distance analysis of Pma1 clusters in wild type and KH238 plasma membranes in the absence and presence of CSF treatment. h Analysis of average cluster radius in wild type and KH238 plasma membranes in the absence and presence of CSF treatment. wild type (-): n = 14; wild type (+): n = 16; KH238 (-): n = 19; KH238 (+): n = 7. (-/+) indicates without or with CSF treatment. Scale bars, 100 nm. Box plots in (g) and (h) show the median (centre line), the 25th and 75th percentiles (bounds of the box), and whiskers extending to 1.5× the interquartile range. Source data are provided as a Source Data file.
