Fig. 7: Integration with scRNA-seq data improves scHi-C embedding performance.
From: A comprehensive benchmark of single-cell Hi-C embedding tools
a Standalone embeddings human PFC scHi-C data with scGAD (up panel) and an independent human brain scRNA-seq data (bottom panel). b Integration of scHi-C with scRNA-seq embedding using Harmony. Top left: scRNA-seq cells visualized in joint embedding space; Top right: scHi-C cells visualized in co-embedding space (scRNA-seq data is grayed out); bottom left: only neurons from scRNA-seq data are visualized in co-embedding space; bottom right: only neurons cells from scHi-C data are visualized in co-embedding space. Note that nearly all neuron subtypes are distinguishable in the joint embedding.
