Fig. 7: Conserved and divergent molecular features of the mouse, tree shrew, and human SC.
From: Co-Conservation of synaptic gene expression and circuitry in collicular neurons
A UMAP plot of integrated neurons from the SC of mice, tree shrews, and humans. B Heatmap showing the percentage of neurons from each subtype in the two-species integrated dataset (TM – tree shrews and mice), mapped to clusters in the three-species integrated dataset (HTM – humans, tree shrews, and mice). C Percentage distribution of SSI between mice and humans for all genes and the cluster markers (top 50 for each cluster). D GO enrichment analysis on the top 50 cluster markers using a one-sided hypergeometric test with Benjamini-Hochberg correction for multiple comparisons. E Sankey plot illustrating the mapping of human neurons within cluster HTM21 from the HTM.integrated dataset, along with TM.integrated clusters, to the subclusters of HTM21. F Heatmap showing the progressively enriched expression of 1,152 genes from mice to tree shrews to humans. G GO enrichment analysis on genes showing increased expression from mice (M) to tree shrews (T) to humans (H) using a one-sided hypergeometric test with Benjamini-Hochberg correction for multiple comparisons. H Heatmap showing the expression of 71 primary cilium assembly-related genes across neuronal clusters in the HTM.integrated dataset. I GO analysis on the top 1500 genes most conserved in expression across the three species using a one-sided hypergeometric test with Benjamini-Hochberg correction for multiple comparisons. J Schematic summarizing the conserved and divergent molecular features of the mouse, tree shrew, and human SC.
