Table 1 Optimization of short-chain 1,1-PA synthesis†
Entry | Deviation from standard condition | Yield | DP |
|---|---|---|---|
1 | Standard condition | 60% | 15.4 |
2 | IPrCuCl instead of cat I | 0% | / |
3 | IPrAgCl instead of cat I | 0% | / |
4 | 10 mol% Zn(OAc)2 + 11 mol% L1 | 27% | 7.8 |
5 | 5 mol% catalyst instead of 10 mol% | 29% | 15.5 |
6 | Phenol 1 instead of propofol | 46% | 14.0 |
7 | 2,4,6-trimethylphenol instead of propofol | 38% | 17.3 |
8 | Phenol instead of propofol | 31% | 10.1 |
9 | EtOH instead of propofol | 70% | 9.2 |
10 | 100 °C instead of 80 °C | 41% | 14.3 |
11 | 60 °C instead of 80 °C | 40% | 12.0 |
12 | 5 bar instead of 2 bar | 37% | 12.8 |
13 | Balloon pressure instead of 2 bar | bad reproducibility | |
