Table 1 Cohort characteristics

From: CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial

 

Baseline N = 35

3 months N = 30

6 months N = 31

9 months N = 31

12 months N = 26

15 months N = 23

18 months N = 22

21 months N = 22

24 months N = 19

Controls N = 49

Sex

Female n (%)

18 (51%)

15 (50%)

16 (52%)

15 (48%)

12 (46%)

13 (57%)

12 (55%)

12 (55%)

9 (47%)

29 (59%)

Age in years

Median (IQR)

24 (13, 31)

24 (12, 30)

25 (13, 33)

25 (14, 31)

27 (14, 32)

28 (23, 35)

29 (23, 36)

28 (24, 34)

30 (24, 43)

24 (18, 33)

min-max

6–53

6–53

6–53

6–53

6–54

9–54

13–54

13–54

14–55

6-56

Age groups

>=20 n (%)

23 (66%)

20 (67%)

20 (65%)

21 (68%)

18 (69%)

18 (78%)

17 (77%)

17 (77%)

15 (79%)

32 (65%)

12-19 n (%)

4 (11%)

4 (13%)

5 (16%)

5 (16%)

5 (19%)

4 (17%)

5 (23%)

5 (23%)

4 (21%)

13 (27%)

<=11 n (%)

8 (23%)

6 (20%)

6 (19%)

5 (16%)

3 (12%)

1 (4.3%)

0 (0%)

0 (0%)

0 (0%)

4 (8.2%)

Mutation

F508del homozygous n (%)

26 (74%)

23 (77%)

24 (77%)

23 (74%)

19 (73%)

18 (78%)

18 (82%)

17 (77%)

16 (84%)

 

Lung function

ppFEV1 Median (IQR)

82 (68, 99)

97 (85, 109)

98 (82, 105)

97 (78, 108)

87 (75, 105)

88 (75, 100)

84 (73, 102)

81 (68, 103)

79 (69, 91)

 

ppFVC Median (IQR)

94 (84, 106)

107 (98, 121)

103 (97, 113)

102 (98, 114)

102 (95, 111)

103 (95, 111)

102 (93, 108)

102 (93, 111)

98 (90, 104)

 

Sweat chloride

[mmol/l] Median (IQR)

86 (79, 96)

50 (42, 56)

  

44 (32, 59)

 

50 (27, 56)

 

46 (35, 53)

 

Bacterial culture results1

Sputum

Staphylococcus aureus pos. n (%)

11 (61%)

4 (40%)

3 (60%)

5 (71%)

1 (20%)

1 (17%)

2 (40%)

2 (40%)

1 (17%)

 

Pseudomonas aeruginosa pos. n (%)

10 (56%)

4 (40%)

2 (40%)

2 (29%)

3 (60%)

2 (33%)

2 (40%)

2 (40%)

1 (17%)

 

No culture results n (%)

17 (49%)

20 (69%)

26 (84%)

24 (77%)

21 (81%)

17 (74%)

17 (77%)

17 (77%)

13 (68%)

 

Throat

Staphylococcus aureus pos. n (%)

17 (71%)

20 (69%)

19 (66%)

17 (59%)

11 (44%)

9 (45%)

11 (55%)

11 (50%)

6 (32%)

 

Pseudomonas aeruginosa pos. n (%)

5 (21%)

5 (17%)

3 (10%)

4 (14%)

2 (8.0%)

3 (15%)

3 (15%)

4 (18%)

5 (26%)

 

No culture results n (%)

11 (31%)

1 (3%)

2 (6%)

2 (6%)

1 (4%)

3 (13%)

2 (9%)

0 (0%)

0 (0%)

 
  1. 1 We compared bacterial culture results to detection of Pseudomonas and Staphylococcus with 16S rRNA gene sequencing. Accuracy between methods ranged from 90% for Pseudomonas in throat samples to 54% for Staphylococcus in throat samples, results are summarized in Supplementary Data 15.
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