Fig. 2: Development of GEM.
From: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
A The Spearman correlation between mutation burden and chronological age stratified by chromHMM annotations in CD34 + cells. B The Spearman correlation between mutation burden and chronological age stratified by functional consequence as annotated by the variant effect predictor (VEP). C The Spearman correlation between mutation burden and chronological age, stratified by quintiles of CADD scores. D Plate annotation for the GEM statistical model. θ_0 and are intercepts; θ_1reflects the association between the log2-transformed value of ∑z_ij and chronological age Y_i; z_ij denotes the probability that the jth mutation in the ith individual is a true somatic mutation. X is a matrix of annotations.
