Fig. 4: The consequence of SMC4 and NRIP1 knock down on HSC self-renewal.
From: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
A SMC4 and NRIP1 were knocked-down with shRNA, and the proportion of CD34 + cells was quantified with FACs. Quantities were compared referent to a non-targeting control. B proportion of CD34 + CD38- was quantified with FACS. C Number of colonies formed in a colony-forming unit (CFU) assay. D Number of colonies in a burst-forming unit assay. A linear model was used to estimate effect sizes across technical replicates (n = 4). Error bars indicate 95% confidence intervals.
