Fig. 5: The sex specific genetic determinants of mutation burden.
From: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
A Regressions were performed for each quantile-transformed somatic principal component (sPC) on study and sex as covariates. The partial variance explained by sex is displayed on the y-axis. B Circular Manhattan plot. The outer-most ring is the GWAS of GEM on all individuals, the middle ring is the GWAS of GEM on males (λ^gc = 0.99), and the inner-most ring is the GWAS of GEM in females (λ^gc = 0.99). Inset, a scatter plot of the two sex-specific GWAS plotting all SNPs with p-values < 1 × 10-8 in either GWAS. Asymptotic confidence intervals are plotted with a width corresponding to genome-wide significance.
