Fig. 1: IRE1α pathway and reported IRE1α RNase inhibitors. | Nature Communications

Fig. 1: IRE1α pathway and reported IRE1α RNase inhibitors.

From: Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing

Fig. 1: IRE1α pathway and reported IRE1α RNase inhibitors.

a Illustration of the IRE1α pathway showing the three main downstream effects, the XBP1 splicing, the induction of apoptosis and autophagy, and the regulated IRE1α-dependent decay (RIDD). ER endoplasmic reticulum. UPR unfolded protein response. b Examples of reported IRE1α inhibitors targeting either the kinase domain or the ribonuclease domain (PDB ID: 4PL3).

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