Fig. 6: Proposed biochemical function of anglerases and its phylogenetic relationships with the DUF4198 and DUF6702.
From: Signal-strapping as a protein-sequence search method for the discovery of metalloproteins
a Overall full-length modelled structure of RbAng-1a-HupE/UreJ-2 (green) in the close and open positions on the context of the membrane/cell wall system of gram-negative bacteria. Analysis of RbAng-1a-HupE/UreJ-2 CDS in the DeepLoc server67 revealed a putative localisation of the TM HupE/UreJ-2 domain at the cytosol membrane of gram-negative bacteria, and RbAng-1a at its periplasm. b Overall full-length modelled structure of MmAng-2a-HupE/UreJ-2 (magenta) in the closed and open positions on the context of the membrane/cell wall system of gram-negative bacteria. Analysis of MmAng-2a-HupE/UreJ-2 CDS in the DeepLoc server67 revealed a putative localisation of the TM HupE/UreJ-2 domain at the cytosolic membrane of gram-positive bacteria, and MmAng-2a at the outer cell space. c Phylogenetic tree of the herein identified metalloproteins. IsDUF4198 is in bold red, followed by PaDUF6702 in purple, RbAng-1a in blue and MmAng-2a in yellow. Source data are provided as a Source Data file.
