Fig. 6: Excess sperm production and continuous germline proliferation shorten lifespan in mog-3(-) worms.
From: Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans
a Survival curves showing the lifespans of wild-type N2 and mog-3(q74) worms upon spe-26 RNAi. b Survival curves showing the lifespans of wild-type N2 and mog-3(q74) worms upon FUDR treatment. In (a and b), two biological replicates were analyzed for each genotype. The detailed mean lifespan values, the number of worms analyzed in each replicate, and statistical analysis for (a and b) are provided in Source Data. c, d Representative DAPI-stained images of whole worms in mog-3(q74) upon mock (c) and FUDR treatment (d). e, f Representative EdU -stained images of dissected gonads in mog-3(q74) upon mock (e) and FUDR treatment (f). Scale bars in (c–f), 50 µm. FUDR 5-Fluoro-2′-deoxyuridine; DAPI 4′,6-diamidino-2-phenylindole; EdU 5-ethynyl-2′-deoxyuridine.
