Fig. 8: Cell type and temporally specific expression of matrisome genes associated with NDDs. | Nature Communications

Fig. 8: Cell type and temporally specific expression of matrisome genes associated with NDDs.

From: Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis

Fig. 8: Cell type and temporally specific expression of matrisome genes associated with NDDs.

a Bar graphs displaying number of matrisome marker genes (y-axis) in each cell type (x-axis) associated with NDD. b Volcano plot illustrating differentially expressed matrisome genes in microglia and endothelial cells. The top five significantly upregulated and downregulated NDD associated matrisome genes are labeled (ranked by log₂ fold-change, adjusted p-value < 0.05). c Heatmap displaying the expression levels of up to the top five NDD-associated matrisome genes across different cell types (ranked by log₂ fold-change, adjusted p-value < 0.05). d Heatmap displaying the expression levels of up to the top five NDD associated matrisome genes across three developmental periods in all cell type (ranked by log₂ fold-change, adjusted p-value < 0.05). In b–d, differential expression was assessed using DESeq2 (negative binomial GLM, two-sided Wald test) with Benjamini–Hochberg FDR correction; effect size is log₂ fold-change with 95% Wald confidence intervals (n = as specified in Supplementary Fig. 1d).

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