Fig. 2: Cryo-EM maps reveal additional non-proteinaceous densities in L1 Aβ₄₀ fibrils with anle138b. | Nature Communications

Fig. 2: Cryo-EM maps reveal additional non-proteinaceous densities in L1 Aβ₄₀ fibrils with anle138b.

From: Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Fig. 2: Cryo-EM maps reveal additional non-proteinaceous densities in L1 Aβ₄₀ fibrils with anle138b.The alternative text for this image may have been generated using AI.

Lipidic Aβ₄₀ fibril data in the absence of anle138b were previously published and is included here for comparison. a Exemplary 20 Å low-pass filtered cryo-EM micrographs and 2D class averages for different fibril preparations: control condition (without anle138b), post-treatment condition, and pre-treatment condition. b Cross-sections of the cryo-EM maps showing L1 Aβ₄₀ fibrils under the three conditions. c Overlay of a sharpened high-resolution cryo-EM map (transparent surface representation) and the atomic model (stick representation) of the fibril: control condition: gray (without anle138b), post-treatment condition: blue, and pre-treatment condition: red.

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