Fig. 1: A new paradigm in patient-matched scaffold-guided bone regeneration. | Nature Communications

Fig. 1: A new paradigm in patient-matched scaffold-guided bone regeneration.

From: Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration

Fig. 1: A new paradigm in patient-matched scaffold-guided bone regeneration.The alternative text for this image may have been generated using AI.

Current clinical practice (Conventional paradigm) uses vascularized autologous bone grafts that are transplanted from anatomically disparate sites to be reshaped and fixated with Ti plates. This approach is associated with considerable morbidity from tissue harvest, and the suboptimal material properties of Ti increase the risk of non-union and impair radiological surveillance. The new paradigm uses 3D-printed artificial bone (LS-PEK) that is custom-made for the individual’s defect site, numerically optimized for osteoconduction, thermally toughened for strength, and surface-treated for osseointegration, thus avoiding the morbidity of bone grafts and the need for metal plate augmentation. Created in BioRender. Crook, J. (https://BioRender.com/e8aq7lf).

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