Nature Communications

Table 3 Regression estimates from female-stratified associations with consistent effects across two of three brain regions

From: Sex-specific associations of gene expression with Alzheimer’s disease neuropathology and ante-mortem cognitive performance

				DLPFC				PCC				CN
Outcome	Chr	Gene	Model	Beta	SE	T	P_FDR	Beta	SE	T	P_FDR	Beta	StdError	T	P_FDR
Tangles	5	NNT	Female	−0.21	0.05	−3.99	0.01	−0.31	0.07	−4.74	0.005	−0.05	0.06	−0.8	0.72
			Male	−0.03	0.05	−0.59	0.78	−0.04	0.06	−0.68	0.82	−0.07	0.06	−1.2	0.52
	17	MYO15A	Female	−0.21	0.05	−3.95	0.01	−0.07	0.07	−0.96	0.7	−0.22	0.06	−3.69	0.03
			Male	−0.04	0.05	−0.86	0.66	−0.05	0.06	−0.92	0.74	−0.03	0.06	−0.52	0.81
Cognition	1	XKR8	Female	−0.03	0.01	−4.21	0.001	−0.01	0.01	−1.03	0.7	−0.04	0.01	−4.07	0.01
			Male	−0.01	0.01	−1.34	0.63	−0.03	0.01	−3.65	0.02	−0.01	0.01	−0.85	0.74
	2	GCA	Female	0.01	0.01	1.92	0.16	0.03	0.01	3.76	0.04	0.03	0.01	3.1	0.05
			Male	0.01	0.01	1.39	0.62	0	0.01	0.2	0.95	0	0.01	−0.4	0.89
	4	GALNT7-DT	Female	−0.03	0.01	−4.08	0.001	0.01	0.01	0.56	0.86	−0.03	0.01	−3.24	0.04
			Male	0.003	0.01	0.47	0.89	−0.01	0.01	−1.43	0.48	0	0.01	−0.31	0.92
	10	WBP1L	Female	−0.02	0.01	−3.73	0.004	−0.01	0.01	−0.57	0.86	−0.03	0.01	−3.27	0.04
			Male	−0.003	0.01	−0.48	0.89	−0.02	0.01	−2.59	0.13	0	0.01	−0.3	0.92
	19	MVB12A	Female	−0.03	0.01	−3.94	0.002	−0.02	0.01	−2.73	0.17	−0.04	0.01	−4.4	0.003
			Male	−0.002	0.01	−0.28	0.94	−0.02	0.01	−1.76	0.35	−0.01	0.01	−0.91	0.71
	19	PEPD	Female	−0.03	0.01	−4.1	0.001	−0.01	0.01	−1.42	0.57	−0.04	0.01	−4.65	0.002
			Male	−0.01	0.01	−1	0.75	−0.01	0.01	−0.83	0.72	−0.01	0.01	−1.53	0.47
	20	CTNNBL1	Female	−0.02	0.01	−3.08	0.02	−0.03	0.01	−4.04	0.02	−0.02	0.01	−2.01	0.25
			Male	0.0001	0.01	0.01	0.998	0.01	0.01	1.71	0.37	0.01	0.01	1.12	0.63

DLPFC dorsolateral prefrontal cortex, PCC posterior cingulate cortex, CN caudate nucleus, SE standard error, T t-value.
Sex-specific gene associations were defined as related to a trait in one sex (p_FDR ≤ 0.05) but not in the other sex in stratified analyses and showed suggestive evidence of a sex-modifying effect in interaction analyses (sex x gene interaction p < 0.05, uncorrected). Results were FDR-corrected. Significant values are bolded. Number of genes in each brain region: DLPFC (n = 926, genes = 17,088 (autosomal), 562 (X-linked), 63 (Y-linked)); PCC (n = 518, genes = 18,385 (autosomal), 598 (X-linked), 71 (Y-linked)); CN (n = 706, gene = 17,928 (autosomal), 591 (X-linked), 76 (Y-linked)).

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