Table 4 Regression Estimates From Sex x X-Linked Gene Interactions in the DLPFC with pFDR ≤ 0.10

From: Sex-specific associations of gene expression with Alzheimer’s disease neuropathology and ante-mortem cognitive performance

Outcome

Gene

Analysis

β

SE

T

PFDR

Tau Tangles

MCF2

Sex x MCF2

0.28

0.07

3.74

0.052

Male-stratified

0.10

0.05

1.94

0.26

Female-stratified

−0.18

0.06

−3.33

0.02

HDAC8

Sex x HDAC8

−0.30

0.08

−3.82

0.052

Male-stratified

−0.08

0.05

−1.60

0.37

Female-stratified

0.22

0.06

3.75

0.01

Longitudinal Cognition

SLC10A3

Sex x SLC10A3

0.04

0.01

3.69

0.06

Male-stratified

0.02

0.01

2.51

0.24

Female-stratified

−0.02

0.01

−2.7.

0.04

FTX

Sex x FTX

0.04

0.01

3.82

0.06

Male-stratified

0.02

0.01

3.58

0.0496

Female-stratified

−0.02

0.01

−2.06

0.13

  1. @@DLPFC dorsolateral prefrontal cortex; SE standard error; T = t-value.
  2. Genes presented here met sex-specific gene association criteria and additionally had a sex x gene interaction that met significance set a priori at pFDR ≤ 0.10. Results were FDR-corrected. Significant values are bolded.