Fig. 1: Heterogeneity of TDP-43 inclusions in FTLD-TDP and ALS.
From: The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies
Photomicrographs of representative morphologies for FTLD-TDP subtypes (A–D) and ALS (E) tissue immunostained for phosphorylated TDP-43 (pS409/410). A FTLD-TDP morphological subtype A with superficial layer short dystrophic neurites (arrows) and neuronal cytoplasmic inclusions (asterisks) containing pathological TDP-43, B FTLD-TDP subtype B with mainly neuronal cytoplasmic inclusions (asterisks), C FTLD-TDP subtype C with long ropy dystrophic neurites (arrows), and D FTLD-TDP subtype D associated with pathogenic variants in valosin-containing protein (VCP) with superficial layer lentiform neuronal intranuclear inclusions (asterisks) and short dystrophic neurites (arrows) while E ALS shows skin-like inclusions (arrows) in anterior horn motor neuron. Scale bar = 100 μm. Reproduced and modified from Irwin et al.16.
