Table 2 The OSRs after the collective adjustment for all CDPs collected for this study and the CDPs of certain disease class (14 classes defined by WHO ICD-11) calculated across fifteen nine-year time-windows
From: Dynamic clinical trial success rates for drugs in the 21st century
Disease class | 2001–2009 | 2002–2010 | 2003–2011 | 2004–2012 | 2005–2013 | 2006–2014 | 2007–2015 | 2008–2016 | 2009–2017 | 2010–2018 | 2011–2019 | 2012–2020 | 2013–2021 | 2014–2022 | 2015–2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | 16.7% | 14.3% | 12.3% | 11.1% | 9.8% | 8.9% | 9.2% | 8.6% | 8.7% | 8.6% | 8.4% | 8.6% | 8.9% | 8.6% | 8.1% |
01 INFEC | 20.7% | 20.4% | 19.6% | 17.1% | 11.9% | 10.8% | 13.4% | 12.3% | 10.3% | 8.5% | 7.1% | 7.1% | 8.0% | 6.0% | 3.9% |
02 CACER | 15.2% | 13.2% | 11.6% | 10.4% | 9.4% | 7.8% | 7.4% | 6.7% | 6.7% | 6.3% | 6.0% | 6.1% | 6.0% | 5.8% | 5.7% |
03 BLOOD | 59.9% | 58.0% | 36.9% | 40.7% | 38.4% | 32.4% | 33.7% | 34.8% | 37.4% | 35.5% | 35.9% | 41.9% | 39.3% | 32.6% | 34.1% |
04 IMMUN | 35.1% | 43.3% | 33.2% | 26.4% | 23.7% | 18.7% | 15.3% | 12.7% | 14.6% | 14.4% | 11.5% | 12.2% | 15.3% | 15.6% | 15.0% |
05 METAB | 17.4% | 14.7% | 10.3% | 10.0% | 8.8% | 8.6% | 9.8% | 10.0% | 10.4% | 12.0% | 12.2% | 12.2% | 14.3% | 13.3% | 12.8% |
06 NEURO | 17.3% | 12.4% | 10.3% | 7.8% | 6.5% | 5.5% | 5.3% | 6.1% | 6.7% | 6.6% | 8.7% | 10.4% | 10.6% | 13.0% | 13.0% |
07 VISAL | 20.3% | 18.1% | 14.0% | 14.0% | 10.5% | 10.8% | 11.1% | 11.1% | 11.8% | 11.2% | 9.2% | 9.3% | 11.0% | 10.8% | 11.2% |
08 CIRCU | 10.3% | 8.6% | 6.5% | 7.0% | 7.4% | 7.9% | 8.9% | 7.3% | 7.4% | 8.6% | 6.6% | 5.9% | 7.1% | 5.8% | 4.7% |
09 RESPR | 9.6% | 9.0% | 8.9% | 7.7% | 7.4% | 7.8% | 7.5% | 6.8% | 6.3% | 6.0% | 6.2% | 5.5% | 7.8% | 7.2% | 7.0% |
10 DIGST | 8.6% | 8.4% | 10.6% | 11.2% | 12.1% | 9.7% | 10.5% | 8.9% | 10.1% | 12.6% | 13.4% | 12.1% | 12.5% | 12.6% | 9.3% |
11 SKINS | 8.4% | 13.3% | 9.9% | 7.4% | 5.1% | 7.3% | 10.6% | 9.6% | 10.6% | 12.5% | 12.0% | 12.3% | 13.8% | 13.9% | 15.0% |
12 MUSKE | 24.8% | 19.7% | 18.0% | 17.6% | 16.3% | 14.0% | 13.1% | 11.6% | 9.9% | 9.8% | 10.0% | 8.9% | 8.4% | 8.1% | 8.7% |
13 GENIT | 14.4% | 10.9% | 7.8% | 5.8% | 9.4% | 12.2% | 11.5% | 13.3% | 15.0% | 16.6% | 19.1% | 21.2% | 15.7% | 8.8% | 8.1% |
14 OTHER | 13.3% | 9.7% | 12.3% | 10.7% | 10.3% | 9.9% | 11.7% | 11.0% | 10.8% | 9.1% | 7.8% | 10.8% | 11.0% | 10.1% | 8.5% |
