Fig. 6: Several KZFPs in the BL6J Chr4 cluster bind to ERVs that display only a mild enrichment within the Chr4 cluster itself.

a Bubble heatmap plot of TE binding of BL6J Chr4 cluster KZFPs (pValue < 0.001 from permutation test), determined by ChIP-seq experiments (top). Bubble size indicates the percentage of peaks overlapping with the distinct TEs over the total peaks for each KZFP; bubble color indicates the Z-score of the peak overlap over TEs, calculated by permutation test. KZFPs are sorted by similarity of the fingerprint array (tree on the left). KZFPs without an identical fingerprint array match in 129S1 or CAST strains are highlighted in blue. The enrichment of each TE within the Chr4 KZFP gene cluster locus compared to genome-wide in different mice and rat is also shown (bottom). TE enrichment is shown as log2 of the ratio between the percentage of the KZFP gene cluster annotated as the TE (bp) and the percentage of the whole genome annotated as the TE (bp). Grey tiles indicate complete absence of the TE family in the corresponding locus. b IGV snapshot of multiple KZFPs targeting RLTR4_MM-int ERVs. c IGV snapshot of KZFPs targeting either the LTRs or the internal portion of IAPEz elements.