Fig. 2: Scope of synthesis of two classes of boron–stereogenic compounds. | Nature Communications

Fig. 2: Scope of synthesis of two classes of boron–stereogenic compounds.

From: Rhodium-catalyzed construction of boron-based point and axial chirality via asymmetric annulation of alkynylborons

Fig. 2: Scope of synthesis of two classes of boron–stereogenic compounds.The alternative text for this image may have been generated using AI.

[a] Reaction conditions A: 1 (0.12 mmol), 2 (0.10 mmol), (R)-Rh3 (4 mol%), AgBF4 (16 mol%) and CCA (50 mol%) in toluene (2 mL), 0 °C, 48 h. [b] AgOTf (16 mol%) and MesCOOH (2 equiv) was used. [c] Reaction conditions B: 1 (0.12 mmol), 3 (0.10 mmol), (R)-Rh3 (4 mol%), PhCOOAg (50 mol%) and HOAc (0.20 mmol) in toluene (2 mL), 40 °C, 24 h. Isolated yield. The enantioselectivity was determined by HPLC analysis using a chiral stationary phase.

Back to article page