Fig. 4: Comparison of previously suggested MIR domain Man-binding sites with the observed Ccw5 peptide-binding site in Pmt4. | Nature Communications

Fig. 4: Comparison of previously suggested MIR domain Man-binding sites with the observed Ccw5 peptide-binding site in Pmt4.

From: Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins

Fig. 4

Suggested Man-binding sites α, β, γ, and δ in the crystal structures of the Pmt2 MIR domain (PDB ID 6ZQP, a) and Man-binding site α in the Pmt3 MIR domain (PDB 6ZQQ, b). c The Ccw5 peptide in the Pmt4 MIR domain. The three dashed magenta circles indicate Man sites α, β, and γ in the Pmt2 MIR. d Sketch showing that the previously suggested Man-binding sites do not overlap with the observed substrate-peptide-binding site in the Pmt4 MIR domain. The red circle represents the Mannose molecules.

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