Fig. 6: Model of mitochondrial CIC recruitment to Salmonella-containing vacuoles (SCVs) and SCV detoxification.
From: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
After invasion, Salmonella Typhimurium remodels host endomembranes to position mitochondria in close proximity to the Salmonella-containing vacuole (SCV). The SPI-2 effector SseF links the late-endosomal GTPase RAB7 to the mitochondrial citrate/isocitrate carrier CIC (SLC25A1), forming a RAB7-CIC complex that promotes CIC translocation from mitochondria to the SCV membrane. Once at the SCV, CIC exports citrate/isocitrate, reducing intravacuolar reactive oxygen species (ROS). By lowering ROS, Salmonella evades oxidative defenses, enabling continued replication and survival within the SCV. The figure was created in BioRender.
