Fig. 6: The genetic overlap of the corpus callosum and neuropsychiatric phenotypes.
From: The Genetic Architecture of the Human Corpus Callosum and its Subregions
a Global genetic correlations between CC traits and neuropsychiatric phenotypes. Significance was based on a two-sided Z-statistic. Significant results are designated by the * at the Bonferroni significance threshold of p = 0.0015. Significant negative genetic correlations are observed between total and splenium thickness, and bipolar disorder (I). Significant negative genetic correlations are also observed with CC area phenotypes and ADHD. Of the significant global genetic correlations, significant Mendelian randomization (GSMR) results are displayed, representing the effect of CC phenotypes on neuropsychiatric phenotypes free of non-genetic confounders. The number of SNPs used in the GSMR analysis were N = 29 for BD on total mean thickness, N = 26 for BD-I on total mean thickness, N = 11 for total mean thickness on BD, N = 25 on BD-I on splenium mean thickness, and N = 11 on total mean thickness on BD-I. Data are presented as beta values +/− s.e. b Volcano plots showing degree (-log10 p-values) and direction (rG) of local genetic correlations (LAVA) between neuropsychiatric and CC phenotypes. Significant local negative genetic correlations on the STH, KANSL1, SPPL2C, CRHR1, and MAPT genes are observed between the genu area and neuroticism. Significant local positive genetic correlations on the MAPT, SPPL2C, STH, CRHR1, ARHGAP27, KANSL1, PLEKHM1, MAP3K14, and DCAKD genes are observed between the genu area and Parkinson’s disease. A significant positive local genetic correlation is observed on the CEP170 gene between total mean thickness and Parkinson’s disease. Significance was tested as a two-sided t-test statistic. Phenotypes with significant associations are colored (IQ and bipolar II disorder). Significant genes (Bonferroni significance threshold was set at p = 2.79 × 10−6) across all neuropsychiatric phenotypes are shown. AD Alzheimer’s disease, ADHD attention deficit hyperactivity disorder, ASD autism spectrum disorder, BD bipolar disorder, BD-I bipolar I disorder, BD-II bipolar II disorder, COPC chronic overlapping pain conditions, IQ intelligence quotient, OCD obsessive-compulsive disorder, PD Parkinson’s disease, PTSD post-traumatic stress disorder, SCZ schizophrenia.
