Fig. 1: CMTR2 cluster in the AS landscape of LADC. | Nature Communications

Fig. 1: CMTR2 cluster in the AS landscape of LADC.

From: Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities

Fig. 1

a Schematic showing the study workflow. The bar graph on the left shows the number of tumor samples of each histological type in the NCC lung cancer cohort. Abbreviations: ADC, adenocarcinoma; ASC, adenosquamous carcinoma; LCC, large cell carcinoma; LCNEC, large cell neuroendocrine carcinoma; PC, pleomorphic carcinoma; SCC, squamous cell carcinoma; SCLC, small cell lung carcinoma. b Types of AS events detected by rMATS. c–g AS landscape of LADC samples from the NCC cohort, analyzed based on SE PSI values. Each t-SNE plot reflects the reduction in the higher-dimensional splice event PSI matrix for each sample into two dimensions. t-SNE plots are color-coded according to driver genes (c), type of U2AF1 mutation (d), type of RBM10 mutation (e), smoking status (f), and type of CMTR2 mutation (g). h RNA cap structure. Methylation sites and the corresponding methyltransferases are indicated. The chemical structure was modified from CHEBI:167614 obtained from the ChEBI database (https://www.ebi.ac.uk/chebi/). i Frequency of each CMTR2 mutation type in the TCGA PanCancer Atlas.

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