Fig. 3: P. goldsteinii increased as a result of LRD has significant anti-obesity effects. | Nature Communications

Fig. 3: P. goldsteinii increased as a result of LRD has significant anti-obesity effects.

From: A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid

Fig. 3: P. goldsteinii increased as a result of LRD has significant anti-obesity effects.The alt text for this image may have been generated using AI.

a Bubble chart showing the abundance differences of the 7 most abundant species in the fecal microbiota of mice from each group after 8 weeks of different dietary treatment. b–e Spearman correlation of the abundance of P.goldsteinii in feces with body weight, AUC of GTT, HOMA-IR and plasma lysine concentrations of mice and linear regression line with 95% confidence interval. f Differences in the abundance of P. goldsteinii in the feces of Leptin KO mice. g Differences in the abundance of P. goldsteinii in feces of healthy controls and children with obesity (N = 18 or 20). h Flow chart of the animal experiments. i Differences in the abundance of P. goldsteinii in feces of mice at the end of experiment between mice administrated with P. goldsteinii or PBS. j, k Body weight and body weight gain in each group of mice during the 12-week experiment. l Differences in body size of mice between each group after 4 weeks of P. goldsteinii/PBS treatment. m–p Glucose metabolism of mice from each group at the end of experiment including GTT, AUC of GTT, ITT and AUC of ITT. q, r Fasting insulin concentrations and HOMA-IR. s The weights of liver and eWAT of mice from each group after the 12-week treatment. t Pathological changes in the eWAT of mice, including H&E stained sections (representative images) (scale bars, 50 μm and 100 μm) and the area of fat cells. Each circle represents an independent experimental group (a). Each point in graphs (b–f, i, k, n, p–s) represents the value obtained in an independent mouse (n = 6 or 8 per group). Data were presented as mean ± S.E.M. P values were calculated with the Kruskal-Wails H rank sum test (a), Spearman correlation analysis (two-tailed) (b–e), unpaired two-tailed Student’s t test (f, l, n, p–s), two-tailed Mann-Whitney test (g, k), two-way ANOVA repeated-measure with Sidak’s multiple comparisons test (j, m, o) and exact P value were shown in figure panels. Source data are provided in a Source data file.

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