Fig. 4: Scope of alkenes.
From: Harnessing nitroarenes as nitrogen and oxygen sources for general oxo-aminomethylation of alkenes
Nitroarene (N1 or N16 or N37, 1.0 equiv., 0.10 mmol), N,N-dimethylcyclohexylamine (A1, 6.0 equiv.), alkene (O2–O35, 10.0 equiv., 1.0 mmol), 4CzPN (PC4, 3 mol %), Ni(bipy)Cl2 (20 mol %), Hantzsch ester (1.8 equiv.), NMP (1 mL), ~40 °C, blue LEDs (30 W, 455–460 nm), 24 h. Isolated yields are shown. X-ray crystallography of 49 and 71 data were obtained (see Supporting Information for details). a1,3-Oxazinanes were formed in 23–45% yield as co-products (see supporting Information for details).Me methyl, Cy cyclohexyl, Boc tert-butoxycarbonyl, BPin pinacol boronate, Et ethyl, Ph phenyl, Bn benzyl; tBu tert-butyl.
