Fig. 1: Distribution of CEs in the pan-Cancer ORIEN IO cohort. | Nature Communications

Fig. 1: Distribution of CEs in the pan-Cancer ORIEN IO cohort.

From: Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors

Fig. 1: Distribution of CEs in the pan-Cancer ORIEN IO cohort.

A This heatmap displays the abundance profiles of cell states and CEs identified across all cancer types in the ORIEN IO cohort. Only samples assigned to pre-defined CEs (CE1-CE10) are included. Each column in the heatmap corresponds to RNA sequencing samples (n = 1340), and each row shows the expression of cell state marker genes within a recovered ecotype. B Pie charts illustrate the distribution of the ten CEs within five specific cancer groups: melanoma, head and neck cancer (H&N), non-small cell lung cancer (NSCLC), kidney cancer, and bladder cancer. Each segment indicates the number of assigned patients per ecotype group—abbreviations: CE, carcinoma ecotype; S, cell state. C Average cellular composition of the ten melanoma ecotypes (n = 118 melanoma samples). The left panel shows immune cell proportions estimated using the original CIBERSORT method (using LM22 as reference). The right panel shows cellular composition estimated using CIBERSORTx with a melanoma-specific single-cell RNA-seq reference (Tirosh dataset15).

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