Fig. 9: Transcriptomic analysis of tumor tissues treated with self-driven electrical triggering system (BTO-CPT/FA). | Nature Communications

Fig. 9: Transcriptomic analysis of tumor tissues treated with self-driven electrical triggering system (BTO-CPT/FA).

From: Self-driven electrical triggering system activates tunneling nanotube highways to enhance drug delivery in bladder cancer therapy

Fig. 9

a A volcano plot illustrating the upregulated and downregulated genes among the differentially expressed genes in the control and BTO-CPT/FA groups. b A heatmap of the differentially expressed proteins. c and d GSEA demonstrating positive enrichment of differentially expressed genes (DEGs) in cellular processes. e Gene Ontology (GO) enrichment analysis of DEGs between the control and BTO-CPT/FA groups. f Enrichment analysis for DEGs triggered by BTO-CPT/FA treatment. g Chordal plots of kyoto encyclopedia of genes and genomes (KEGG) pathway analysis after treatment with BTO-CPT/FA. h GO enrichment analysis of the DEGs after treatment with control or BTO-CPT/FA groups. i GO enrichment of the DEGs related to microtubules after treatment with BTO-CPT/FA. j Functional association networks of variably expressed microtubule-associated proteins. k Mechanism of tunneling nanotubes formation among MB49 cells after treated by BTO-CPT/FA. Source data are provided as a Source Data file. Figure 9k was created in BioRender. Xixi, L. (2025) https://BioRender.com/vpcd32z.

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