Fig. 2: dGCNA uncovers the functional context of genes corresponding to canonical and non-canonical T2D pathways of beta cells.

A Hierarchical clustering dendrogram and clustering of eleven NDCGs in beta cells. Genes with high intramodular connectivity are located at the tip of the module branches since they display the highest interconnectedness with the rest of the genes in the module. Colors represent clusters detected by the dynamic tree cutting algorithm. B Plotting the top enriched GO-terms (Biological process) for each NDCG across all NDCGs revealed a high degree of specificity in terms of biological annotation. Columns represent NDCGs and rows are top GO-terms. C Scatter plots representing coordination rank scores for genes in each NDCG, with degree of negative (N) and positive (P) scores indicated in red. D Plot of differentially expressed genes (pseudo-bulk DESeq2, merged dataset, FDR corrected). See also Supplementary Data 2 and Figs. S2–S4 and S11.