Fig. 6: Somatic hypermutation levels in ConM SOSIP.v7-specific memory B cells. | Nature Communications

Fig. 6: Somatic hypermutation levels in ConM SOSIP.v7-specific memory B cells.

From: HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial

Fig. 6

V-gene somatic hypermutation (SHM) levels (%) within the ConM SOSIP.v7-specific memory B-cell population, measured at 26 weeks and 48 weeks for A the complete (N = 23) per-protocol cohort (p = 0.048), B the Full dose group (N = 13) and Fractional (Fx) dose group (N = 10), C female (N = 13) and male (N = 10) participants (week 26 p = 0.00086; week 48 p = 1.7 × 10−5), D, E female and male participants per vaccine group, per time point. Full dose female (N = 7), Full dose male (N = 6), Fx dose female (N = 6), Fx dose male (N = 4) (D week 26 p = 0.0023; week 48 p = 0.00045; E week 48 p = 0.042). Box plots indicate median SHM values, 25th and 75th percentiles; whiskers represent minima and maxima. Differences between groups and sex were calculated by two-sided Wilcoxon signed rank test, paired comparisons were calculated by donor median SHM two-sided paired Wilcoxon signed rank test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = not significant (p > 0.05). Source data are provided as a Source Data file. Sequence data were uploaded to a public repository (see ‘Data Availability’).

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