Fig. 7: IL-6 secretion by PBMCs following ConM SOSIP.v7/MPLA stimulation. | Nature Communications

Fig. 7: IL-6 secretion by PBMCs following ConM SOSIP.v7/MPLA stimulation.

From: HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial

Fig. 7

PBMCs were incubated for 24 h with ConM SOSIP.v7 (5 µg/mL) and MPLA (30 µg/mL). Subsequently, supernatant was removed and IL-6 levels were determined using ELISA. Data is visualised for all participants, comprising female (N = 13 at both time points) and male study participants (N = 9 at baseline due to missing sample, N = 10 at 10 weeks). Box plots indicate median values, 25th and 75th percentiles; whiskers represent minima and maxima. Statistical testing was performed between both groups using repeated measures two-way NOVA followed by a Tukey multiple comparisons test. *p = 0.030, ****p < 0.0001, ns = not significant. Source data are provided as a Source Data file.

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