Fig. 2: At the compartment scale, H3.3 redistribution in the absence of HIRA is not accompanied by corresponding H3 PTM changes.
From: HIRA defines early replication initiation zones independently of their genome compartment
a Active (H3K4me1/3, H3K27ac) and inactive (H3K9/27me3) PTM enrichment at 10 kb bins at compartments A and B from WT and HIRA KO HeLa cells, sorted by size and centered at their middle ±2.5 Mb. b Compartment assignment and eigenvector tracks at 50 kb resolution and enrichment of H3.3, H3.1, active (H3K4me1/3, H3K27ac) and repressive (H3K9/27me3) PTMs from HIRA WT and KO cells (chr13: 45–80 Mb). ChIP-seq is shown at 10 kb bins smoothed over 3 non-zero bins. H3.3, H3.1, PTM enrichment shown is z-score of log2 IP/input.
