Fig. 1: The first three structure-function components across the AD-FTD spectrum.
From: Functional network collapse in neurodegenerative disease
A The correlation between atrophy and functional connectivity (FC) scores for partial least squares regression components 1-3. Beneath each correlation plot are the associated atrophy patterns associated with a negative or positive atrophy component score. For component 1, three example patients are shown with different atrophy patterns but equivalent overall mean atrophy. B Matrices showing the partial least squares FC weights for each component, along with the network membership for each brain region. Negative and positive weights indicate a decrease or an increase in FC with an increase in the atrophy component score (and vice versa). Matrices show 14 brain FC networks for reference. The top row of brain surfaces shows the 14 networks. The bottom row of brain surfaces shows the FC PLSR region sums. VIS visual, SM sensory-motor, DA dorsal attention network, AUD auditory, HIP hippocampal, PHC parahippocampal, AMY amygdala, CO cingulo-opercular, SAL salience, AT anterior temporal, FPl left fronto-parietal, DMN default mode network, FPr right fronto-parietal, SUB subcortical. AD Alzheimer’s Disease. bvFTD behavioral variant FTD. CBS corticobasal syndrome, nfvPPA nonfluent variant primary progressive aphasia, svPPA semantic variant primary progressive aphasia, CN cognitively normal.
