Fig. 2: Atrophy and functional connectivity patterns for each syndrome.

Central scatter plot depicts individual subjects’ atrophy similarity in two dimensions based on multidimensional scaling of structure components 1-3. Large dots show the mean position for each clinical syndrome. For each syndrome, the mean atrophy pattern and functional connectivity matrix are shown for the set of “typical” patients that were accurately classified as having that syndrome based on their individual atrophy pattern. The mean functional connectivity difference matrix is shown for the typical patients for each syndrome versus cognitively normal subjects (upper triangles), along with the reconstructed matrix based on function components 1-3 (lower triangles). AD Alzheimer’s Disease, bvFTD behavioral variant FTD, CBS corticobasal syndrome, nfvPPA nonfluent variant primary progressive aphasia, svPPA semantic variant primary progressive aphasia, CN cognitively normal.