Fig. 6: Gradient eigenmode relationships with different structure-function components.
From: Functional network collapse in neurodegenerative disease
A–D Left to right: the correlation between each subject’s gradient temporal variance/covariance and gradient amplitude/angle; the atrophy components associated with higher or lower gradient amplitude/angle; illustration of the gradient amplitude/angle differences and the resultant simulated timeseries; and the gradient spatial maps. A Gradient 1 amplitude associated with atrophy component 1. Gradient amplitudes and timeseries are shown for subjects in the 20th and 80th percentile of atrophy component 1. B Gradient 1-4 angle associated with atrophy component 1. Gradient phase angles and timeseries are shown for subjects in the 20th and 80th percentile of atrophy component 1. R-values show correlation between the simulated gradient timeseries. C Gradient 1-2 angle associated with atrophy components 3 and 2. Gradient phase angles and timeseries are shown for subjects in the 10th and 90th percentile. D Gradient 2 amplitude associated with atrophy component 3. Gradient amplitudes and timeseries are shown for subjects in the 20th and 80th percentile of atrophy component 3. AD: Alzheimer’s Disease; bvFTD: behavioral variant FTD; CBS: corticobasal syndrome; nfvPPA: nonfluent variant primary progressive aphasia; svPPA: semantic variant primary progressive aphasia; CN: cognitively normal.
