Fig. 4: Distribution patterns of microsatellite instability (MSI) status of different genes in different groups and characteristics of patients with LS harboring germline co-occurring susceptibility mutations.
From: Clinical and genomic features of Lynch syndrome differ by tumor site and disease spectrum
A The numbers of different MSI status in different germline genes among the three groups are depicted, with distinct colors representing various MMR genes. The sample number is indicated on the y-axis. B Pie chart indicating the distribution of MSS tumors (blue), MSI-H tumors (dark orange) and MSI-L tumors (yellow) with respect to different germline genes among the three cohorts. C The TMB, MSI and germline MMR gene signatures of different cancer types for each sample were analyzed. The tumor types are indicated on the x-axis. TMB is indicated on the y-axis. The shape indicates the MSI status. The colors indicate the germline genes. D The characteristics of patients with LS harboring germline co-occurring susceptibility mutations. The different colors correspond to different characteristics, as indicated. Each column represents an individual patient. Source data are provided as a Source Data file.
